The NASA Headquarters Library is located in Washington, DC at 300 E Street, SW, on the corner of 4th and E. The building is also called Two Independence Square. The garage in the building is only for NASA Headquarters employees. Parking is available on the surrounding streets. A map of the immediate vicinity is on the NASA Headquarters website. The closest Metro station is Federal Center SW on the Blue and Orange lines.

The Library is open from Monday-Friday, 7:30 - 5:00, except Federal holidays.

The Library is open to everyone, although some services are limited to NASA Headquarters employees. No appointment is necessary. Visitors should enter NASA Headquarters through the West Lobby. The Library is adjacent to the West Lobby security desk, through the waiting room.

The Library reserves the right to deny access to any visitors who do not follow library policies.