The NASA Headquarters Library is located in Washington, DC at 300 E Street, SW, on the corner of 4th and E. The building is also called Two Independence Square. The garage in the building is only for NASA Headquarters employees. Parking is available on the surrounding streets. A map of the immediate vicinity is on the NASA Headquarters website. The closest Metro station is Federal Center SW on the Blue and Orange lines.

The Library is open from Monday-Friday, 7:30 - 5:00, except Federal holidays.

The Library is open to everyone, although some services are limited to NASA Headquarters employees. No appointment is necessary. Visitors should enter NASA Headquarters through the West Lobby and stop at the guards' desk. They should indicate they wish to visit the library and present current valid government photo identification. Foreign nationals are signed in by library staff and issued badges at the guard's desk.

The Library reserves the right to deny access to any visitors who do not follow library policies.